The Sisters of the Precious Blood is a Roman Catholic female religious order founded in 1845 in Steinerberg, Switzerland by Magdalene Weber and a number of young women from Baden.
Young women from Baden, Germany joined together for the perpetual adoration of the Most Precious Blood in the Blessed Sacrament, under the guidance of Karl Rolfus.
In 1857, Herman Kessler, pastor of Gurtweil, Baden, who had long desired to establish a home for destitute children and a normal school for the training of religious teachers, asked for six members of the community of the Sisters of the Precious Blood from Ottmarsheim, Alsace.
Under the auspices of Hermann von Vicari, the archbishop of Freiburg, a novitiate and normal school were established; the latter was affiliated with the educational department of Karlsruhe.
With anti-Catholic sentiment growing in Germany, American bishops offered the opportunity to minister to newly arrived German immigrants.
Meantime Peter Joseph Baltes succeeded Junker as bishop; he entrusted to them several parochial school and promised further assistance on condition that the community should establish itself permanently in his diocese subject to his authority.
In September, Muehlsiepen met forty-nine sisters in New York and conducted them to St. Louis, where the new Motherhouse in O'Fallon, Missouri was completed by July, 1875.
Clementine Zerr, with ten professed sisters and a number of novices at Belle Prairie, chose to maintain affiliation with the Precious Blood Congregation in Rome.