She is a member of the United Malays National Organisation (UMNO), a component party of the BN coalition.
On 13 June 2018, Siti Berenee was appointed as the Perlis State EXCO Member in charge of Women, Family, Community Development, Community Unity, and Special Tasks by Menteri Besar Azlan.
She won the seat and was elected into the Perlis State Legislative Assembly as the Mata Ayer MLA after defeating candidates of Pakatan Harapan (PH) and Gagasan Sejahtera (GS) by a majority of 720 votes.
In the 2022 Perlis state election, Siti Berenee was renominated by BN to defend the Mata Ayer seat.
She lost the seat and was not reelected as the Mata Ayer MLA for the second term after losing to Wan Badariah Wan Saad of Perikatan Nasional (PN) by a minority of 2,021 votes.