Six Mile is a town in Pickens County, South Carolina, United States.

The climate is mild and temperate with rainfall evenly distributed throughout the year.

As the showers decrease, a secondary dry period occurs late in April and early May.

The average date of the last spring freeze falls around the end of March, which gives the area a growing season of approximately 180–200 days.

Six Mile's warm and pleasant autumn is the driest season of the year with the first frost usually occurring the first week of November.

Of all households, 20.0% were made up of individuals, and 8.0% had someone living alone who was 65 years of age or older.