The Six Nations Chiefs are Canadian Senior box lacrosse team from Six Nations of the Grand River.

The Chiefs play in the Major Series Lacrosse of the Ontario Lacrosse Association.

The Chiefs are seven-time Mann Cup National Senior Champions.

The Chiefs won the Mann Cup Canadian National Senior Championship in 1994, 1995, 1996, 2013, 2014, 2016, 2023, and 2024[1][2]