Griffin played his junior rugby league for the Cobden-Kohinoor Keas, before being signed by the Melbourne Storm.

In a 2012 pre-season trial match, he tore the anterior cruciate ligament in his right knee,[6] ruling him out for the rest of the season, however the Storm decided to extend his contract for another year allowing him to come back from injury.

[6] After 1056 days since his last NRL match, Griffin returned to the Storm line-up in round 15 of the 2016 season, starting at hooker.

[16] In 2017, Griffin was able to break into Melbourne's line-up more regularly, coming off the interchange bench in their 2017 NRL Grand Final win over the North Queensland Cowboys.

[19] In round 1 of the 2018 season, Griffin made his debut for the Knights in their 19-18 golden point extra-time win over the Manly Warringah Sea Eagles, scoring a try.

[23] In July 2020, Griffin was announced as the new coach of the New Zealand Warriors NRL Women's (NRLW) team.