Slagelse station is located on the main line Copenhagen–Fredericia railway from Copenhagen to Funen and Jutland.

[2] Its second and current station building designed by the architect Niels Peder Christian Holsøe was inaugurated in 1892.

[4] The station offers direct InterCity services to Copenhagen, Funen and Jutland, regional rail services to Copenhagen and Odense operated by the national railway company DSB, as well as local train services to Tølløse, operated by the regional railway company Lokaltog.

[1][3] Slagelse station's second and current station building was built from 1891 to 1892 to designs by the Danish architect Niels Peder Christian Holsøe (1826–1895), known for the numerous railway stations he designed across Denmark in his capacity of head architect of the Danish State Railways.

[5] Slagelse railway station is used as a location in the 1942 Danish comedy film Frk.