"Slave to the Rhythm" was originally intended for Frankie Goes to Hollywood as a follow-up to their hit debut single "Relax".

The track proved exceptionally popular in Belgium, New Zealand, Italy and German speaking countries, where it made it to the top 10.

The original version of the single, and its remixes, also topped the American dance chart in February 1986, despite not entering the mainstream Billboard Hot 100 ranking.

[5] The track "Slave to the Rhythm" on the album is in turn a different interpretation of the song—a fact which apparently eluded Universal Music when they included this version in one of their many best-of packages The Ultimate Collection.

The accompanying music video for "Slave to the Rhythm" features the hit single version of the song, billed as "Ladies and Gentlemen: Miss Grace Jones" in the album track listing.

[9] The video starts with dialogue from Ian McShane and shows how the cover art of Slave to the Rhythm was made, a before and after of the cover art image, then it shows a series of clips from archived music videos including "My Jamaican Guy", "I've Seen That Face Before (Libertango)" and the suicide scene from "Living My Life" edited to towards the end to when Jones collapsed and dies.