The film's plot involves an elite commando squad dealing with a deadly and bloodthirsty vampire clan living in the South American rain forest.
There have always been legends about vampires living in the jungle and feeding off animals, but now they are suddenly attacking humans and quite viciously, too.
Of course, the military doesn't buy that they are vampires, just "tribal anomalies who BELIEVE that drinking human blood will give them power," but Colonel Jessica Weaver (Lynda Carter) is sending Captain Tom "Hawk" Hawkins (Casper Van Dien), Sergeant Alex Juarez (Alexis Cruz), and the rest of his platoon back down there to finish the job they started some six months ago when they first encountered these tribal anomalies.
She's already sent Hawk's second-in-command and best friend, Grieves (Kevin Grevioux), a huge, hulking man, on ahead so that he can get a feeling for what is happening.
Hawk and his men are to leave immediately for Agua Caliente, a small town along a river in a no-fly zone, where they are to rendezvous with Grieves and look for Laurie.
Meanwhile, in South America, Laurie, along with her guide, Luiz, and a couple of aides, are making their way through the forest when they come across a young boy threatening a man with a wooden stake.
Laurie, quick-thinker that she is, plays dumb blonde and approaches the boy, speaking to him in bad Spanish... "Porque usted threatenez el hombre?"
With the kid distracted by her act, Laurie quickly grabs the stake and backhands the boy to the ground.
El hombre, whose name is Javier Vasquez (Tony Plana), explains that the boy is from a local village.
Turns out that Javier owns a hotel in Agua Caliente, and he does not have many guests, so he invites Laurie to stay there.
Hawk and his platoon are making their way towards Agua Caliente when they notice the trailmarkers (blue ribbons) left by Laurie.
They decide that they might be able to make better time and cut the risk of vampire attacks by renting a fishing boat and heading to Agua Caliente on water.
At one of them, Hawk runs into an old lady selling a "vampire souvenir" that turns out to be a dogtag from one of Grieves' men.
Before taking her bath, Laurie has tea with Javier, who warns her that she must be careful if she goes into the forest around Agua Caliente.
Still unconvinced about vampires, Laurie goes to bed, only to be awakened to find Estrella, fangs bared and blood on her face, staring down at her.
Then Javier brings out Laurie, who explains to Hawk why the vampires have recently changed their hunting tactics, thanks to man's infringement on the rain forests.
[1] Slayer was released on region 1 DVD in the United States on November 21, 2006, distributed by Anchor Bay Entertainment.
[citation needed] Dread Central awarded the film two out of a possible five mugs of blood and said "Slayer is pretty much what you'd expect; a bit dull, full of hammy acting, logic gaps you could drive a truck through, and ridiculously sparse on the special effects."
[citation needed] Casper Van Dien and Kevin Grevioux earlier appeared in separate vampires films: Dracula 3000 and the Underworld series respectively.