The slimy sculpin is a nocturnal fish that usually spends most of its time on the stream bottom and seeks shelter under rocks and logs, especially during spawning season.

For these reasons, slimy sculpin have been identified as a good indicator species for changes in acidification among lakes, ponds, and streams.

[3] The slimy sculpin can easily be distinguished by its pair of free and independent pelvic fins, as well as not possessing any scales.

[7] The mouth and snout are terminal and very wide, and also contain a band of fine conical teeth in both the upper and lower jaw, but do not possess barbels.

[8] When the fish moves, it is an inconsistently rapid and darter-like motion that looks like it's hopping due to its irregular compressed body shape.

Slimy sculpins often inhabit swift rocky-bottomed cold streams, oligotrophic lakes, and even brackish waters at a preferred temperature range of 9–14 °C.

[8] During the breeding season, females often lay their eggs under sheltered areas like large objects such as rocks or tree roots found at the bottom of lakes or streams that males will guard.

[8] This species is currently at low concern for conservative action and does not need protection or major management plans.