His family hails from the influential Samardžić brotherhood of the Herzegovinan Krivošije clan, specifically from the area near Herceg Novi, in Montenegro.

From 2001 to 2023, Samardžić was a full professor of European Studies at the Faculty of Political Sciences of the University of Belgrade.

[1] Samardžić was advisor for political issues to former Yugoslav president and Serbian Prime Minister Vojislav Koštunica.

[1] He headed the Serbian government’s Committee for Decentralisation and was (with Vuk Jeremić) co-ordinator of Serbia's State Negotiating Team on the future status of Kosovo-Metohija.

Slobodan Samardžić appears in Boris Malagurski's documentary film The Weight of Chains in which he talks about the motives behind Western intervention in the Kosovo War.