Slow-reacting substance of anaphylaxis

The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4.

Mast cells secrete it during the anaphylactic reaction, inducing inflammation.

It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.

[2] Compared to histamine, it is approximately 1000 times more potent and has a slower onset but longer duration of action.

This biochemistry article is a stub.