In molecular biology, snoRNA U59 is an RNA molecule that belongs to the C/D class of snoRNA, which contain the C box motif (UGAUGA) and the D box motif (CUGA).

[1] Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.

There are two closely related copies of U59, called SNORD59A and SNORD59B.

[2] This RNA has been identified in both the human and mouse genomes.

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