After her graduation from the Drama School, in 1937, she was hired by the top theatre star of these times, Marika Kotopouli.
Since 1952 she was the main character actress in the company of Vassilis Logothetidis, with whom she stayed until his death, in 1960.
She also she acted alongside Katerina, Elli Lampeti, Dimitris Horn, Lambros Konstantaras, Giannis Fertis, Xenia Kalogeropoulou, Aliki Vougiouklaki, Stefanos Lineos, Giannis Gkionakis, Nikos Kourkoulos, Antonis Antypas and many more.
A bright point in her career was her rendition of queen Hecuba in the play Trojan Women by Euripides translated and directed by Giannis Tsarouchis at a makeshift theatre on Kaplanon Street and in Delphi At the "Tsarouhis Academy", as she playfully called it, she learned a lot from the charismatic artist.
In autumn 2003 Smaro Stefanidou and her daughter created the "Shantom House of Culture", in Chalandri (a suburb of Athens), a centre hosting lessons, workshops and seminars (dance, yoga, martial arts, theatre, alternative therapies etc...) as well as performances.