After attaining admission to the bar, he settled in the village of Plattsburgh, where he practiced law and became involved in businesses including lumber, mines, and railroads.

Weed attended several Democratic National Conventions as a delegate and was a supporter of Samuel J. Tilden for president in 1876 and 1880.

Weed died on Valcour Island on June 7, 1920, and was buried at Riverside Cemetery in Plattsburgh.

[8] In 1890, Weed was a prominent organizer and financial supporter of his party's effort to take control of the state legislature.

[9] Weed expected to be his party's candidate, but agreed to withdraw if Governor David B. Hill desired the nomination.

[10] Weed was the Democratic US Senate nominee again in 1905; Republicans controlled the legislature, and reelected Chauncey Depew.

[14] Weed's former home at the corner of Sailly Avenue and City Hall Place still stands.