Smithshire is an unincorporated small village in Warren County, Illinois, United States.

Smithshire is located along the BNSF Railway line, 40 miles (64 km) northeast of Fort Madison, Iowa.

Smithshire has a post office serving ZIP code 61478, a restaurant, a church, a grainery complex, and a fire station.

Twomey Company operated in several western Illinois locations, including a barge loading facility on the Mississippi River.

Amtrak’s Southwest Chief, which operates between Los Angeles and Chicago, passes through the town on BNSF tracks, but makes no stop.