[2] Sneha was born as Suhasini Rajaram Naidu on 12 October 1981 into a Telugu family[3] originally from Andhra Pradesh.

[3] Fazil Nazeem recommended Sneha to Anil-Babu who was searching for a heroine for his love story Ingane Oru Nilapakshi (2000).

[6] She was signed by Susi Ganeshan for his directorial debut Virumbugiren in 2000, which however became long delayed and Ennavale, opposite Madhavan, became her first Tamil release.

She started the year 2001 with a foray into Telugu cinema, with an appearance in Priyamaina Neeku, followed by N. Linguswamy's family drama Aanandham.

Virumbugiren that featured Sneha as a rustic village belle, eventually released in December 2002 and went on to win the Tamil Nadu State Film Award for Best Actress.

She received high praise for her performance in Parthiban Kanavu,[11] with The Hindu writing: "Till date this is the best role that has come Sneha's way and the charming actress has utilised the opportunity well.

In the year 2006, she made her debut into Kannada film industry through Ravi Shastri, which released to negative reviews.

[14] In 2007, Sneha starred in Naan Avanillai, Madhumasam, Maharadhi and Tamil film Pallikoodam released to positive reviews.

Ponnar Shankar, a period film penned by M. Karunanidhi, where she appeared as a warrior-princess, opened to mixed reviews and didn't do well at the box office.

[20] Rajanna, a period film based on Telangana issue opposite Nagarjuna for the second time, released on 22 December 2012 to positive reviews.

[22] In 2013, she acted in a critically acclaimed movie Haridas.Her next release was a trilingual made in Kannada, Tamil and Telugu – Un Samayal Arayil (2014), the official remake of the Malayalam blockbuster Salt N' Pepper, where she starred opposite Prakash Raj and a bunch of debutantes.

[28] She acted in lead role in Tamil children's film, Shot Boot Three directed by Arun Vaidyanathan.

[29] Then, Vijay and Sneha, who were last seen together in 2003 release Vaseegara directed by K. Selva Bharathy, will be pairing up after 22 years in Venkat Prabhu's The Greatest of All Time (2024).