The sequel to Sniper Elite III, the game was released for Microsoft Windows, PlayStation 4 and Xbox One on 14 February 2017 and for Stadia on 1 November 2020.

Upon learning about rumours of a new Nazi weapon, the Royal Navy sends a freighter, the Orchidea, to the island of San Celini to investigate.

The ship is quickly sunk by the new weapon – a radio guided anti-ship missile under the development of scientist Andreas Kessler and Heinz Böhm, a high ranking Nazi general that the Allies have little information about.

SOE sniper Karl Fairburne (Tom Clarke-Hill) is sent to the island after the sinking and tasked with assassinating General Tobias Schmidt along with several other officers who oversaw the attack, filming it to use as propaganda.

After eliminating Schmidt, Fairburne is sent to the village of Bitanti by OSS agent Jack Weaver to find Sofia "Angel" Di Rocco, leader of the local Partisan resistance group.

Distrustful of the OSS who allowed her father to be kidnapped by the Nazis, Angel enlists Fairburne to destroy a railway gun at Regelino Viaduct in order to prove himself and convince the group to join forces.

Upon learning the Sicilian Mafia were helping disrupt operations at the dockyard to slow down the shipment of the weapon parts, Fairburne meets with kingpin Salvatore Dinelli who agrees to provide additional assistance after eliminating Piero Capo, leader of the local Black Brigade.

On interrogation, Kessler tells Angel her father is still alive, prompting the Partisans to depart to assault the town of Giovi Fiorini and find Böhm's confidant Major Klaus Rothbauer.

Kessler then tells Fairburne that he is dying of liver cancer due to his heavy drinking and is of no use to the Nazis or the Allies as a result, and that the information given to Angel was a lie in order to lure the Partisans into a trap.

Gathered intelligence allows the SOE to discover Böhm is aware of Operation Avalanche and has the constructed missiles sent to his fortress at Allagra, intending to both inflict enough damage on the fleet to prevent the invasion of Italy from being a success and attempting to kill General Dwight Eisenhower.

[6] As a result, the team expanded the size and scale of the game's maps and levels to make "real long shots" possible.

[9] Rebellion instead partnered with Sold Out and U&I Entertainment, the publishers and distributors of Zombie Army Trilogy, to produce physical copies of the game.

He notes the enemy soldiers' "tunnel vision, short attention spans, and inconsistent pathfinding", but he feels it is "in service of the overall experience".