She was a Filipina suffragette, social welfare worker, private secretary in the office of the President of the Philippines, teacher, school founder, and member of several government boards.

[1] After becoming Assistant Dean of Women at Philippine Normal University, de Veyra pursued further studies in Manila.

[1] De Veyra's studies led her to be one of the first Filipino teachers in Saravia (now Enrique B. Magalona), in Negros Occidental province.

[1] That year, de Veyra helped organize the University's Normal Hall Dormitory, which trained the first Filipino nursing students and recruited young Filipinas from across the country.

[4][5] In 1917, de Veyra moved to Washington, D.C. as a diplomat's wife, and while there gave lectures and was otherwise active in women's clubs.

[6] Sofia de Veyra was also noted for wearing the distinctive Philippine terno formal dress to events and while giving public speeches in the United States.

The club also formed the Little Mother's League, Civic Committee and provided free legal aid for indigent women through Filipina lawyers.

[9] She met with First Lady Florence Harding, and received a certificate of appreciation from the American Red Cross for her contributions during World War I.

[12] She was also appointed head of the domestic science department at Centro Escolar de Señoritas, a girls' school.