Softball competition at the 2022 Bolivarian Games in Valledupar, Colombia were held from 25 to 30 June 2022 at the Estadio Dorismel Pacheco Fontalvo.

[2] Venezuela were the women's softbol competition defending champions having won it in the previous edition in Santa Marta 2017, but they were unable to retain their title after finishing fourth.

Dominican Republic won the gold medal by beating Colombia 12–3 in the final.

[1] All matches will be played at Estadio Dorismel Pacheco Fontalvo located within the Centro de Alto Rendimiento Deportivo La Gota Fría in Valledupar,[4] The Estadio Dorismel Pacheco Fontalvo has a capacity for 1,600 spectators.

The final round was played under the page playoff system in which the top two teams from the preliminary round played a semi-final game, with the winners advancing directly to the gold medal game.