Swimming competitions at the 2022 Bolivarian Games in Valledupar, Colombia were held from 2 to 5 July 2022 at the Aquatics Complex in the Popular University of Cesar cluster, with the marathons swimming being held at Ciénaga de Zapatosa in Chimichagua, a sub-venue outside Valledupar.

[2] Venezuela were the swimming competitions defending champions having won them in the previous edition in Santa Marta 2017.

Colombia obtained 15 of the 40 gold medals at stake to win the swimming competitions.

Pool events took place at the Popular University of Cesar's Aquatics Complex in Valledupar, while open-water events were held at Ciénaga de Zapatosa in Chimichagua, a municipality located 147 km south Valledupar.

[1] Ciénaga de Zapatosa also served as venue for the rowing, canoeing and triathlon competitions.