In particular, they may express molecules of the chemoreceptorial cascade (such as trans-membrane taste receptors, the G-protein gustducin, PLCbeta2, IP3R3, TRPM5).
In the upper respiratory system the SCCs are contacted by the sensory endings of trigeminal nerve fibers (SubP and CGRP immunoreactive).
The SCCs of the aquatic vertebrates play a role in food search and predator avoidance.
The functional role of the SCCs located in internal organs of mammals is unknown also if several hypotheses have been advanced.
In nasal cavity, SCCs operate as sentinels being involved in detection of irritants and are important in the protection of the airway.