Solomon Cohen Sr. (October 13, 1757 – May 23, 1835) was a distinguished merchant and prominent citizen of both Charleston, South Carolina, and Savannah, Georgia, in the 18th and 19th centuries.

[1] His father, born in England in 1709,[1] was a founder and the first Rabbi of Temple Beth Elohim in Georgetown, South Carolina.

Their daughter, Sarah Henrietta, married Savannah's Mordecai Myers II.

"[4] In a letter to his sister-in-law Emma Mordecai (sister of Mordecai Myers I, who married Cohen's sister, Esther), he wrote:[4] [I] believe that the institution of slavery was refining and civilizing to the whites, giving them an elevation of sentiment and ease and dignity of manners only attainable in societies under the restraining influence of a privileged class, and at the same time the only human institution that could elevate the Negro from barbarism and develop the small amount of intellect with which he is endowed.Cohen died on May 23, 1835, aged 77.

He is interred in Savannah's Laurel Grove Cemetery, alongside his wife, who survived him by 27 years.