A music video for the single was directed by Sophie Muller that features the band in an abandoned warehouse space.

"Something Is Not Right with Me" was described by lead singer Nathan Willett as an upbeat track that's about a person losing touch with the revolving world and its constant changes from people to technology.

Joseph Coscarelli of Spin did a stream review and praised the band for its use of "a step-worthy, pounding bass line" and "Stones-styled bluesy licks".

Club was critical about the track, finding fault in Nathan Willett's voice going from "a mere Jack White-style wail to screechy barking" but overall found it to be "an otherwise fine tune".

[8] The video features the band playing in an abandoned warehouse space in which they do random stuff that follows the song's title.