Between 2001 and 2003, on instructions from Mamata Banerjee, Guha intervened in the defense of squatters that were being evicted from the banks of Tolly's Nullah and Gobindapur railway colony.
Guha was first elected to the West Bengal Legislative Assembly in 2001 from the Satgachhia (Vidhan Sabha constituency) on an All India Trinamool Congress ticket.
[5] In the 2006 assembly election Guha defeated Kabita Kayal of the Communist Party of India (Marxist) by about 6,000 votes.
This time her opponent was Barun Naskar from the Communist Party of India (Marxist), whom she defeated by about 18,000 votes.
[4] In the 2016 assembly election, Guha won the Satgachhia (Vidhan Sabha constituency) seat for the fourth time, defeating Paramita Ghosh of the Communist Party of India (Marxist) by about a margin of 17,500 votes.