She then published Casi siempre las tardes (1974), La gota en el cráneo (1976), La semana que no tiene jueves (1978), El ave que todo lo atropella (1980), Caja musical con bailarina incluida (1984), Carcoma con forma de paloma (1986) and Full de reinas (1991), which achieved commercial success.

[4] Other poetry books published by Manzano include Patente de corza (1997), Último regreso a Edén (2007) and Espalda mordida por el humo (2014).

Her book Flujo escarlata won the 1999 Joaquín Gallegos Lara National Fiction Prize in the category Best Short-Story Collection.

[7] Her second short fiction book, Trata de viejas (2015), contains 10 stories filled with black humor that dig into nostalgia, loneliness and other problems of old age.

She subsequently published the novels Que se quede el infinito sin estrellas (2001) and Eses fatales (2005), which Manzano described as "a genocentric discourse in which esses and feces converge as the characteristics of the most profound loneliness" and that explore topics such as literary creations, solitude and lesbian love.