Reyes's debut, The Lesbiana's Guide to Catholic School, was published by Balzer + Bray in May 2022.
[3] Among other honors, the novel was a finalists for the 2022 National Book Award for Young People's Literature.
[5] The novel is about teenage girls who had nonconsensual sexual encounters and aim to expose the perpetrator together.
[6] The Chicago Public Library included The Lesbiana's Guide to Catholic School on their list of the best yound adult novels of 2022.
[10] The following year, it was included on Young Adult Library Services Association's list of Teens' Top Ten.