He played college football for the Georgia Bulldogs and was selected by the New England Patriots in the first round of the 2018 NFL draft.

[1] During his first season with the Patriots, he was a member of the team that won Super Bowl LIII, and scored the game's only touchdown.

[3] Michel was the starting running back for the American Heritage Patriots, beginning in his eighth-grade year there.

[15] In 2017, with true freshman Jake Fromm starting at quarterback for the Bulldogs, the team relied heavily on its senior running backs, Chubb and Michel, to carry the load.

[19] Chubb and Michel's 326 combined rushing yards in the Rose Bowl gave them a combined 8,259 career rushing yards, surpassing Eric Dickerson and Craig James' NCAA Division I Football Bowl Subdivision record of 8,192.

[25] Michel and Isaiah Wynn were the first pair of college teammates selected by the same team in the first round since Auburn players Jason Campbell and Carlos Rogers were taken in the 2005 NFL draft by the Washington Redskins.

[26] Michel suffered a knee injury in training camp causing him to miss the entire preseason and the season-opener against the Houston Texans.

[31] In the next game against the Kansas City Chiefs, he rushed for 106 yards and two touchdowns in a narrow 43–40 victory on Sunday Night Football.

[34] This game was his third time breaking the century mark, making him the first Patriots rookie since Robert Edwards did so in 1998.

[38] In the Divisional Round against the Los Angeles Chargers, Michel had 24 carries for 129 yards and three touchdowns in a 41–28 victory.

[39] During the AFC Championship against the Chiefs, he ran for 113 yards and two touchdowns on 29 carries in the 37–31 overtime road victory.

[40] Michel broke the NFL record for most playoff rushing touchdowns for a rookie, scoring five between the divisional and conference championship games.

[41] On February 3, 2019, he scored the only touchdown of Super Bowl LIII against the Los Angeles Rams, carrying 18 times for a game-leading 94 yards.

[47] Two weeks later against the Jets, Michel rushed 19 times for 42 yards and three touchdowns in the 33–0 shutout road victory.

[51] In Week 3, Michel recorded 140 scrimmage yards (117 rushing, 23 receiving) in the 36–20 victory over the Las Vegas Raiders.

[58] Michel was traded to the Rams on August 25, 2021, in exchange for a fifth and sixth round pick in the 2022 NFL draft.

[70] According to Rams head coach Sean McVay, Michel said his body was telling him it was time to retire.