She was best known for playing Epiphany Johnson in the American ABC soap opera General Hospital (2006—2022) for which she won a posthumous Daytime Emmy Award for Outstanding Supporting Actress in a Drama Series in 2023.

[10] In 1995, Eddy moved to Los Angeles and appeared in such sitcoms as Married... with Children, The Drew Carey Show, Murphy Brown, Seinfeld and Home Improvement.

[11] Often playing comedic parts, Eddy appeared in films Nutty Professor II: The Klumps (2000), Barbershop (2002), Daddy Day Care (2003), Surviving Christmas (2004) and Pee-wee's Big Holiday (2016).

[11] In 2006, Eddy was cast as no-nonsense head nurse Epiphany Johnson on the ABC daytime soap opera, General Hospital on a recurring basis.

[6] Eddy also made guest-starring appearances on Reba, Monk, House, ER, Desperate Housewives, Mike & Molly, 2 Broke Girls, The Middle, Mom and Castle.