Born in Cleveland, Ohio, Sonya Monosoff studied the violin with Louis Persinger.
In its infancy, Monosoff joined the ensemble New York Pro Musica under Noah Greenberg.
In 1974 she formed the Trio Amade (1974–1997) with fortepianist Malcolm Bilson and cellist John Hsu.
Monosoff has given recitals of chamber music in the US, Canada, Europe, Israel, Australia, New Zealand and Hong Kong.
In the vein of Baroque performance, she recorded Biber, Arcangelo Corelli, Francesco Geminiani and J. S. Bach.