Sophia Kleinherne (born 12 April 2000) is a German professional footballer who plays as a defender for Frauen-Bundesliga club Eintracht Frankfurt and the Germany national team.

She made her debut in the Bundesliga on 11 February 2018 (matchday 10), when she played the full game time in the 0-1 home defeat against SGS Essen.

At the U17 World Cup in the same year, she was also part of the German squad, was a regular player, as at the European Championships, and reached the quarter-finals with the team.

In the spring of 2017 followed the debut in the U19 national team, with which they qualified for the European Championship in Northern Ireland in the same year, where they played in two group games and the semi-finals, which they lost 2–1 to France.

In addition to her football career, Kleinherne is studying sports management at a distance learning university and is a soldier in the german army (Bundeswehr), currently in the rank of a Hauptgefreiter (higher private).