Sophia of Saxony (died 1244) was a member of the House of Ascania, and the abbess of Gernrode (r.1220–1244).

[2] Sophia's siblings included Albert I of Saxony and Henry I of Anhalt, the latter of whom was the advocate for the abbey of Gernrode.

[3] Sophia succeeded Adelaide II as abbess of Gernrode in late 1220.

The first recorded reference to Sophia as abbess is found in a charter issued in 1221.

[4] In order to protect the abbey's wealth from embezzlement or theft, Sophia purchased extensive goods in Rieder.