Sophie Augusta of Holstein-Gottorp (5 December 1630 in Gottorp – 12 December 1680 in Coswig) was regent of Anhalt-Zerbst in during the minority of her son from 1667 until 1674.

She was a daughter of Frederick III, Duke of Holstein-Gottorp and Duchess Marie Elisabeth of Saxony.

On 16 September 1649 in Gottorp, she married John VI, Prince of Anhalt-Zerbst.

After her husband died in 1667, she became regent for her minor son Charles William, until he came of age in 1674.

This article about a German duchess is a stub.