Sophie Elisabeth of Schleswig-Holstein-Sonderburg-Wiesenburg (4 May 1653 - 19 August 1684), was a German noblewoman member of the House of Oldenburg and by marriage Duchess of Saxe-Zeitz.

Born in Homburg vor der Höhe, she was the third of fifteen children born from the second marriage of Philip Louis, Duke of Schleswig-Holstein-Sonderburg-Wiesenburg with Anna Margaret of Hesse-Homburg.

From her fourteen full siblings, only seven survived to adulthood: Frederick, Charles Louis, Eleanor Margaret (by marriage Princess of Liechtenstein), William Christian, Sophie Magdalene (Abbess in Quedlinburg), Anna Fredericka Philippine (by marriage Duchess of Saxe-Zeitz-Pegau-Neustadt) and Johanna Magdalene Louise.

In addition, she had two further older half-siblings from her father's first marriage with Catharina of Waldeck-Wildungen, of whom only one survived: Dorothea Elisabeth (by her two marriages Countess of Sinzendorf, Rabutin and Marchioness de Fremonville).

In Wiesenburg on 14 June 1676, Sophie Elisabeth married Maurice, Duke of Saxe-Zeitz as his third wife.