Sophie Hedwig of Saxe-Merseburg (4 August 1660 - 2 August 1686), was a German noblewoman member of the House of Wettin and by marriage Duchess of Saxe-Saalfeld.
Born in Merseburg, she was a child of Christian I, Duke of Saxe-Merseburg and his wife Christiana of Schleswig-Holstein-Sonderburg-Glücksburg.
In Merseburg on 18 February 1680 Sophie Hedwig married Johann Ernest, Duke of Saxe-Coburg-Saalfeld.
Three years before (1677) one of Sophie Hedwig's sisters, Christiane, married Christian, Duke of Saxe-Eisenberg, in turn one of Johann Ernest's older brothers, so probably this marriage was instrumental for her future wedding.
The union produced five children, of whom only two survive adulthood:[1][better source needed] Sophie Hedwig died in childbirth in Saalfeld, two days before her twenty-six birthday.