She is known for appearing in films such as Beautiful Kate, Autumn Blood, After the Dark, Adore, Road Kill, Above Suspicion, Medieval and Blow the Man Down, and starring in the television series Once Upon a Time in Wonderland, The Slap, The Returned, and The Beautiful Lie.

In 2013, Lowe and her fellow McDonald College alumnus Rhys Wakefield co-wrote, co-directed, and starred in the short film A Man Walks Into a Bar...

[13] In 2015, Lowe starred in The Beautiful Lie, an Australian television series broadly based on Leo Tolstoy's novel Anna Karenina, playing Kitty Ballantyne, and filmed Waiting for the Miracle to Come, the feature film debut of Australian documentary filmmaker Lian Lunson.

[14] In 2016, she joined the independent Australian film Bloom,[15] and Philip Noyce's thriller Above Suspicion.

[24] Her second extended play saw a departing of her Alt-folk sound, with EP2 embracing a more Electropop production while remaining as an Alternative record.

To promote the project, Lowe released three singles; "Understand", "Pink Flowers" and "Breathe", the first two end up getting a respective music video.

As 2020, the music video for "Understand" directed by Dean Francis, is no longer available to stream on her YouTube page.

[26] In the same year, she starred in the music video from Australian electronic producer Flume and Canadian singer Kai, titled "Never Be Like You" alongside actor Sam Reid,[27] which has over 40 million views on YouTube.

"[34] In 2018, it was confirmed that Lowe was dating Australian singer-songwriter Vance Joy, after he thanked and called her, "My girlfriend Sophie" in his acceptance speech at the ARIA Music Awards.