Soufli (Greek: Σουφλί, romanized: Souflí) is a town in the Evros regional unit, Greece, notable for the silk industry that flourished there in the 19th century.

Beginning in the 19th century, Soufli became an administrative center of a rich province of almost 60,000 inhabitants, extending on both sides of the Evros valley.

From the records of the Greek Consulate in Adrianople state that in 1858 there was a mutual teaching school in Soufli for which the community put up 6,500 piastres to pay for teachers.

It had entered every house in Soufli, and during the two months of May and June it occupied farmers, merchants and craftsmen and provided significant income.

Known as the Town of Silk, Soufli is also famous for its wine, tsipouro (a local strong alcoholic drink), and cooked meats.

The loss of the inland on the eastern riverside of Evros and the subsequent decrease in population of what was now the Greek province of Soufli resulted in the dwindling of the local market and, consequently, the restriction of the trading and craft activities of the town.

Moreover, the partition of Thrace deprived Soufli from a large part of its estates in the eastern riverside of Evros, which now passed into Turkish possession.

The cultivation of wheat, corn and rye provided the town with self-sufficiency as far as nutrition was concerned, and the inhabitants made use of the empty space among mulberry trees and planted mainly legumes and other early or late cereals (multi-culture).

The decline of sericulture, in combination with the lack of industrial units, has forced the population to move towards urban areas or even abroad.

The purpose of the permanent exhibition housed on the ground floor of the Kourtidis Mansion is to show the pre-industrial techniques by which silkworms were bred (sericulture) and silk was woven.

The first exhibition unit relates the history of silk over time, beginning with China, continuing through Greek and Roman antiquity and Byzantium and covering both the West and the Ottoman period.

An educational programme entitled "Unwinding a cocoon ..., addressed to the first classes of primary scholl and covering traditional sericulture and silk-weaving, has been prepared as part of the MELINA project (Ministry of Culture, Benaki Museum).

Opened in September 2008 in a renovated Neoclassical building (1886) on the main thoroughfare of the town, it displays the full sequence of sericulture (with live silkworms on show most of the year) and shows the more industrial side of silk manufacture and weaving incorporating fully functional machinery and exhibits from the Tsiakiri factory and videos of the various stages and methods of production.