South Carolina Highway 41 (SC 41) is a 121.5-mile (195.5 km) state highway, connecting the Charleston region with eastern portions of the Pee Dee region in South Carolina.

It also provides several key river and swamp crossings in the Pee Dee region.

The next year, a separate portion of the highway was established from the Marion–Dillon county line northward for about 5 miles (8.0 km).

In 1949, its southern terminus was shifted to the northwest in Marion, to then end at what was then part of US 501 (now is US 501 Bus.).

Approximately 25 years later, it was put back on the Andrews bypass; its former path was redesignated as SC 41 Bus.

is a 22.904-mile (36.860 km) alternate route that exists west of the SC 41 mainline path.

It connects Centenary and Fork, via Marion, while the mainline travels through Mullins in this area.