South Carolina Highway 576 (SC 576) is a 3.090-mile (4.973 km) primary state highway in the state of South Carolina.

The highway connects U.S. Route 76 (US 76), west of Marion, to US 501, south-southeast of the city.

SC 576 serves to keep the continuation of the four-lane divided highway that travelers get on in Florence to Myrtle Beach and vice versa.

[2] Established in 1973 as new primary routing, connecting US 76 and US 501 Business/SC 41 Alternate; it was built as a four-lane divided highway; it has remained unchanged since.

[3][4] The entire route is in Marion County.