South Dakota Highway 106 (SD 106) is a 4.935-mile-long (7.942 km) state highway in the northeastern part of the U.S. state of South Dakota.

It links Claire City with Hammer.

SD 106 begins as 455th Avenue at a junction with SD 25 and continues south into Claire City.

It continues south out of the town as Main Street after crossing the railroad tracks before turning east as 106th Street.

[3] The entire route is in Roberts County.