South Dakota State Highway 224 (SD 224) is a 7.962-mile-long (12.814 km) state highway located in south-central South Dakota.

SD 224 begins at Willow Avenue in the town of Alpena in Jerauld County.

The highway travels due east on 221st Street, crossing over a railroad and leaving the town, into Sanborn County.

From the county line, SD 224 continues 5 miles (8.0 km) to a junction with SD 37, where the highway ends.

[2] SD 224 was designated in 1976 on a segment of former South Dakota Highway 32.