The 1920 South Dakota League charter franchises were the Aberdeen Boosters, Huron Packers, Madison Greys, Miller Climbers, Mitchell Kernels, Redfield Reds, Sioux Falls Soos and Wessington Springs Saints.
Mitchell had a 61–36 record under Manager Hank Scharnweber, finishing 3.5 games ahead of the Sioux Falls Soos in the regular season standings to claim the title, as the league had no playoffs for its duration.
Wahpeton, North Dakota newspaper publisher Robert J. Hughes formed the new Wahpeton-Breckenridge, Minnesota franchise, hiring Roy Patterson as manager.
The 1921 league members were the Aberdeen Grays, Huron Packers, Madison Greys, Mitchell Kernels, Redfield Red Sox, Sioux Falls Soos, Wahpeton–Breckenridge Twins and Watertown Cubs.
The Mitchell Kernels won their second consecutive league championship, again finishing ahead of the 2nd place Sioux Fall Soos.
The Fargo Athletics, Jamestown Jimkotans and Valley City Hi-Liners became new league franchises in 1922, joining the Aberdeen Grays, Mitchell Kernels, Sioux Falls Soos, Wahpeton-Breckenridge Twins and Watertown Cubs.
Mitchell finished the 1922 season with a 60–37 record under Manager Hank Scharnweber, 4.5 games ahead of the tied 2nd place teams, the Aberdeen Greys and Fargo Athletics.
The South Dakota League folded on July 17, 1923, with the Sioux Falls Soos in 1st place with a 35–22 record, 0.5 games ahead of the Aberdeen Greys.