The South Eastern Region (Maltese: Reġjun Xlokk) is a former region of Malta.

The region included the southeastern part of the main island of Malta, including the capital Valletta.

XVI of 2009 out of part of Malta Xlokk.

South Eastern Region included parts of the South Eastern and Southern Harbour Districts.

South Eastern Region included 15 local councils: The last South Eastern Regional Committee (Maltese: Kumitat Reġjonali Xlokk) was made up of:[2]