Beyond the I-66 bridge, the river flows through a set of bends before turning to the northeast again, crossing into Clarke County 11 miles (18 km) below I-66.

It widened in the interior to a spacious room where hundreds of Col. John Mosby's raiding troops are said to have hidden from pursuing Union cavalry.

[5] The Shenandoah River was contaminated with mercury which was released by a DuPont rayon manufacturing facility located in Waynesboro, Virginia from 1929 to 1950.

In general, the VDOH states that it is not safe to consume more than two fish per month which are caught on the Shenandoah River in Page, Warren, Augusta, or Rockingham counties.

In 2005, redbreast sunfish and smallmouth bass along a 100-mile (160 km) stretch of the South Fork Shenandoah River began dying of lesions caused by bacteria and fungi.

Although the fish kill eventually wiped out 80% of the adult redbreast sunfish and smallmouth bass, juvenile populations appeared to be unaffected.

The North Fork is 105 miles (169 km) long[3] and rises in northern Rockingham County, along the eastern flank of Shenandoah Mountain in the George Washington National Forest.

On the north end of the ridge it turns briefly southeast to join the South Fork from the northwest to form the Shenandoah.