South Miami Senior High School is a high school located at 6856 SW 53rd Street in Glenvar Heights,[2][3] unincorporated Miami-Dade County, Florida, in the United States; located about a mile and a half west of the University of Miami.

South Miami Senior opened its doors to students on November 10, 1971.

The school's first principal, Warren Burchell, was originally from Ohio and chose the school colors, orange and brown, for the team colors of the NFL Cleveland Browns.

Since opening, South Miami has had eight principals: Dr. Warren G. Burchell, Judy Weiner, Thomas L. Shaw, Eugene Butler, Craig Speziale, Gilberto Bonce, Dr. Cadian Collman-Perez, and Hebert Penton.

The school is 84% Hispanic, 8% Black, 7% White non-Hispanic, and 1% Asian.