Of particular focus is Stan Marsh, Kyle Broflovski and Eric Cartman, who find themselves reevaluating their strained friendship and the consequent toll it has on their friend Kenny McCormick.

Meanwhile, former President Garrison returns to South Park, but is met with hostility by the populace; his only support comes from QAnon adherents opposing the people's vaccination efforts.

At school, Eric Cartman and Kenny McCormick play a prank on their teacher, Margaret Nelson, that involves her sitting on a packet of ketchup so that she appears to be menstruating.

Mr. Garrison, having finished his term as President, returns to South Park with his assistant, Mr. Service, to resume his profession as a teacher, being hired in Nelson's place.

Facing backlash over their prank, Cartman, Kenny, Stan Marsh, and Kyle Broflovski decide to make amends by obtaining vaccines for their teachers, under the pretense of forming the Kommunity Kidz.

The boys gain entry to Walgreens by bribing an already-vaccinated elderly woman; upon being found out, they escape with a tray of vaccines, with several townspeople in pursuit.

[9] Ben Travers with IndieWire gave the episode a B grade, and closed his review with the question "(Matt) Stone and (Trey) Parker can do whatever they want with 'South Park.'

'The Vaccination Special' toes that line between giving fans a pleasing throwback to classic seasons while also exploring the idea that you can't really ever go back to normal.