Union), the Southeast Iowa Conference (Cardinal, Central Lee, Columbus Community, Highland, Lone Tree, Louisa–Muscatine, Mediapolis, Pekin, and Wapello), plus Aquinas, Cardinal Stritch, and Marquette Catholic[1] to provide an upgrade in football schedules[citation needed] and to provide competition for non-athletic events such as speech, music, and art.

For one, the Iowa High School Athletic Association took complete control of the football scheduling by implementing the current district format.

[citation needed] Since the conference's founding, three schools have closed (Ft. Madison Aquinas and Marquette of West Point in 2005, and Cardinal Stritch in Keokuk in 2006.)

The conference added Maharishi and Iowa Mennonite in 1996–97 and Ft. Madison Holy Trinity joined the league in 2005 as Aquinas's successor.

[2] At the start of the 2022–2023 school year, the Cardinal Comets departed the SEISC for the South Central Conference.