The Southern Hotel is a three-story Classical Revival structure located in El Reno, Oklahoma.

Listed on the National Register of Historic Places in 1978, the building was constructed in 1909 as a hotel for passengers traveling the Rock Island Railroad as well as travelers along the Oklahoma Railway Company's interurban line to Oklahoma City.

[3] After railroad passenger travel was discontinued through El Reno in 1967, the hotel began to be neglected.

The building was restored in the 1980s; it is used for apartments and small offices, and has been the home of the El Reno Senior Citizens Center for several decades.

This article about a property in Oklahoma on the National Register of Historic Places is a stub.