The Rock Island Depot is a one-story brick structure in El Reno, Oklahoma.

Built in 1907 on the railroad tracks that ran along the western boundary of the Unassigned Lands that led to El Reno's settlement in 1889, it served as a passenger and freight terminal for the junction of the east–west and north–south lines of the Rock Island Railroad.

The one-story building is notable for its length, 176 feet (54 m), but otherwise maintains the standard depot design.

Brick walls in front of the depot and on the platforms were originally installed.

This article about a property in Oklahoma on the National Register of Historic Places is a stub.