Southwestern Indiana's topography is considerably more varied and complex than most of Indiana, from large tracts of forest, marshes, rolling fields, large flat valleys in the west and south, to several chains of low mountains, high hills, and sharp valleys towards the north and east.

More than 50% of the boundaries of Daviess, Knox, Perry, Posey, and Spencer Counties are dictated by a river or a creek.

Additionally, over half of the area is located within the Wabash Valley seismic zone along with neighboring Southeastern Illinois.

[1][2] In addition, the southern third of Southwestern Indiana exists within the Ohio River Valley American Viticultural Area, the second-largest wine appellation in the United States.

U.S. Route 150 Coterminous with US 50 from Vincennnes to Shoals, it breaks off and heads eastward while US 50 continues northeast.

The route is in a process of relocation, as a new four-lane road is under construction from Rockport to Greene County, where it will intersect with Interstate 69.

Most prevalent was the complaint that the Crane Naval Surface Warfare Center had become a "time island".

The workers' union of the base subsequently petitioned the Martin County Commissioners to repetition for a change back to Eastern Time.

However, three of the five counties, Daviess, Knox, and Pike, had little support either, but "convenience of commerce" was given as the reason for their time changes, despite commute patterns into Evansville and the Toyota Motor Manufacturing Indiana plant in Gibson County, the region's largest employer.

Most of Huntingburg's industry and economy is geared towards the Central Time Zone, where Owensboro, Kentucky, and Spencer County, and the Huntingburg area's largest employers, AK Steel and Holiday World, are located.

[4] The final result was that Daviess, Dubois, Knox, Martin, and Pike counties returned to the Eastern Time Zone on November 4, 2007, once again dividing Southwestern Indiana.