Southworth & Hawes

Its partners, Albert Sands Southworth (1811–1894) and Josiah Johnson Hawes (1808–1901), have been hailed as the first great American masters of photography, whose work elevated photographic portraits to the level of fine art.

Writing in the Photographic and Fine Art Journal, August 1855, the contemporary Philadelphia daguerreotypist Marcus Aurelius Root paid them this praise: "Their style, indeed, is peculiar to themselves; presenting beautiful effects of light and shade, and giving depth and roundness together with a wonderful softness or mellowness.

Among their sitters were Louisa May Alcott, Lyman Beecher, Benjamin Butler, William Ellery Channing, Rufus Choate, Cassius Marcellus Clay, Charlotte Cushman, Richard Henry Dana Jr., Dorothea Dix, Ralph Waldo Emerson, Edward Everett, William Lloyd Garrison, Grace Greenwood, Oliver Wendell Holmes, Sam Houston, Thomas Starr King, Louis Kossuth, Jenny Lind, Henry Wadsworth Longfellow, Horace Mann, Donald McKay, Lola Montez, George Peabody, William H. Prescott, Lemuel Shaw, Harriet Beecher Stowe, Charles Sumner, Daniel Webster, John Greenleaf Whittier, and Robert C. Winthrop.

Less than three weeks later, the so-called "Death of Pain" took place on October 16, when Dr. Morton administered ether to a patient before Dr. John Collins Warren, senior surgeon at the Massachusetts General Hospital, removed a tumor from his neck.

Although it is believed that ether anesthesia had been administered for surgery earlier, most notably by Dr. Crawford Long in Jefferson Georgia on March 30, 1843, it had been done privately and not reported in the medical literature.